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Chronic Obstructive Pulmonary Disease

Flashcards: Flashcards

Smoking Mutations

• Alfa 1-antitrypsine
• Glucocorticoid receptor (40%) Excacerbations cAMP & regulation of airway smooth muscle function https://doi.org/10.1016/j.pupt.2012.05.007 + SABA/LABA

Pathogenesis

• Inflammation
• Empysema
• Protease–antiprotease imbalance
• Oxidative stress

Treatment

1. Inhalers
   • Beta-antagonists are bronchodilators
     • Short Acting Beta Agonist (SABA) - beta-2 agonist inhalers – such as salbutamol and terbutaline
       • antimuscarinic inhalers – such as ipratropium https://link.springer.com/article/10.1186/1465-9921-7-73
     • Long Acting Beta Agonists (LABA)
       • beta-2 agonist inhalers – such as salmeterol, formoterol and indacaterol
       • antimuscarinic inhalers – such as tiotropium, glycopyronium and aclidinium
   • Corticosteroids
2. Tablets
   • Theophylline
   • Mucolytics
   • Steroid tablets
   • Antibiotics